Pierre‐Antoine Dugué

The paper identifies a causal epigenetic link between TRIM61 methylation and age at menarche through genome-wide DNA methylation analysis and Mendelian randomisation.

The paper introduces SAM-DNMT3A, a CRISPR-based method to induce global DNA methylation, and shows it exploits a vulnerability in ER-positive breast cancers.

This study identifies CpG sites associated with BMI and shows that epigenetic BMI prediction correlates with metabolic health markers.

This study investigates the causes of variation in DNA methylation age across the lifespan, finding that environmental factors, particularly shared ones, are the main drivers.

This study identifies 137 genome-wide significant loci associated with DNA methylation biomarkers of ageing using DNAm and SNP data from over 41,000 individuals.

This study identifies novel DNA methylation associations with smoking, replicates previous findings, and shows significant reversibility of methylation changes after smoking cessation.