Chenggui Yao

Dissociating the intensity and phase origins of sleepiness through a threshold-distance model of sleep-wake dynamics

The paper resolves the ambiguity in sleepiness prediction by decomposing it into intensity and phase axes using a threshold-distance model, linking sleepiness to both homeostatic pressure and circadian modulation.

Circadian-Modulated Thresholds for Sleep Patterns in Aging and Narcolepsy

This paper derives circadian-modulated sleep thresholds from a biophysical model, showing aging and narcolepsy as opposite deformations along the orexinergic axis.

Circadian-Modulated Thresholds as a Mechanistic Basis for Sleep-Wake Transitions, Recovery, and Sleepiness

This paper develops a computational model that explains sleep-wake transitions and sleepiness through circadian-modulated thresholds, showing how circadian and homeostatic drives interact dynamically.

Mechanistic Modeling of Sleep-Wake Transitions via Circadian-Modulated Threshold Dynamics

This study updates a computational model of sleep-wake regulation by introducing circadian-modulated thresholds, capturing key sleep phenomena and offering insights into circadian misalignment effects.