Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mapping
Inês Pinheiro, John R.D. Dawson, Nicolas Calo, Marianne Paolini‐Bertrand, Kalyana Bharati Akondi, Gavin Tan, Tracy M. Handel, Irina Kufareva, Oliver Hartley
This study identifies a non-canonical activation mechanism of CCR9 by CCL25 through structural modeling and mutational analysis, revealing the 30s loop as the key activation region.
Nature Communications · Aug 18, 2025Peer-reviewedMolecular Biology