Multi-omic characterization of antibody-producing CHO cell lines elucidates metabolic reprogramming and nutrient uptake bottlenecks
Saratram Gopalakrishnan, William Johnson, Miguel Á. Valderrama-Gómez…·Nathan E. Lewis
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Amgen (United States)ORCID 0000-0002-0962-7550Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Saratram Gopalakrishnan, William Johnson, Miguel Á. Valderrama-Gómez…·Nathan E. Lewis
Saratram Gopalakrishnan, William Johnson, Miguel Á. Valderrama-Gómez…·Nathan E. Lewis
COSMIC-dFBA predicts cell density, antibody titer, and metabolite concentrations in bioreactors by integrating machine learning with genome-scale metabolic models.
Saratram Gopalakrishnan, Chintan Jagdishchandra Joshi, Miguel Á. Valderrama-Gómez…·Nathan E. Lewis
The paper evaluates algorithms for generating context-specific metabolic models using gene expression data and identifies guidelines for selecting the best models.