Jasmine Tat

The paper uses SEC-seq to analyze metabolic and secretory strategies in CHO cells, finding that high IgG-producing clones use distinct translation-focused metabolic states.

The paper presents secRecon, a comprehensive secretory pathway reconstruction, and uses it to identify secretory differences in plasma cells and CHO cells, highlighting potential targets for improving secretion capacity.

COSMIC-dFBA predicts cell density, antibody titer, and metabolite concentrations in bioreactors by integrating machine learning with genome-scale metabolic models.