BioinformaticsbioRxivPreprint
H2O: A Foundation Model Bridging Histopathology to Spatial Multi-Omics Profiling
Yunjie Gu, Zihan Wu, Rui Yan…·Jianhua Yao
H2O predicts spatial transcriptomics and proteomics from H&E images using a contrastive learning framework, outperforming existing models and recovering biologically relevant cell-cell communication.