Author

Haoran Lai

University of Science and Technology of ChinaORCID 0000-0002-1549-474XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Approach:contrastive learning· 1 Research Focus:dimensionality reduction· 1 Organism:human· 1 Assay:imaging· 1 Approach:large language model· 1 Assay:proteomics· 1

Frequent Co-Authors

Jianhua YaoiD· 1 shared Rui YaniD· 1 shared Senlin Lin· 1 shared Shaohua Kevin ZhouiD· 1 shared Xin Luo· 1 shared Yan Cui· 1 shared Yuan LiiD· 1 shared Yunjie GuiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBioinformatics

Jianhua YaoORCID

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1 paper

Recent·Most cited

H2O: A Foundation Model Bridging Histopathology to Spatial Multi-Omics Profiling

Yunjie Gu, Zihan Wu, Rui Yan, Zhikang Wang, Yuan Li, Senlin Lin, Yan Cui, Haoran Lai, Xin Luo, Shaohua Kevin Zhou, Zhiyuan Yuan, Jianhua Yao

H2O predicts spatial transcriptomics and proteomics from H&E images using a contrastive learning framework, outperforming existing models and recovering biologically relevant cell-cell communication.

bioRxiv · Apr 24, 2026 · PreprintBioinformatics