In situ evidence that mast cells release mutant NLRP1 in keratoacanthomas from multiple self-healing palmoplantar carcinoma
Alexandra Dobre, Tudor Emanuel Fertig, Andrei Marian Niculae, Adelina-Maria Cohn, Antoanela Curici, Razvan Theodor Andrei, Daciana Silvia Marta, Victor Eduard Peteu, Roua Gabriela Popescu, George Cătălin Marinescu, Gabriela Turcu, Ana‐Maria Forsea, Daniela Adriana Ion, Mihaela Gherghiceanu, Roxana Nedelcu
The paper identifies mutant NLRP1 in mast cell granules in keratoacanthomas associated with multiple self-healing palmoplantar carcinoma, showing overpopulation and degranulation of mast cells expressing the A66V variant.
International Journal of Molecular Sciences · Apr 23, 2026Peer-reviewedImmunology