Age-Associated Decline in Autophagy Pathways in Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light-induced Outer Retinal Degeneration in Mice
Katherine H. M. Cox, Gongyu Shi, Neve Read, Mohamed T. Patel, Kepeng Ou, Zijia Liu, Jiahui Wu, Suci Cendanawati, Jenna Le Brun Powell, Pola Goldberg Oppenheimer, Lisa J. Hill, Lindsay B. Nicholson, Andrew D. Dick, Jian Liu
This study shows age-related autophagy decline in RPE contributes to AMD, and topical trehalose improves autophagy and protects against light-induced retinal damage in mice.
Aging Cell · Apr 28, 2025Peer-reviewedPathology