Recognition of pathogenic bacteria by intestinal progenitors promotes adult Drosophila midgut regeneration via PGRP-MKK3-p38 signalling.
Bhavin Uttekar, Rebecca Wafer, Suci Cendanawati, Parthive H. Patel
This study shows that Drosophila midgut progenitors detect pathogenic bacteria via PGRP-LC/LE and activate MKK3-p38 signaling to drive ISC proliferation and midgut regeneration.
bioRxiv · May 22, 2025 · PreprintDevelopmental Biology