Author

Lukas Frey

ETH ZurichORCID 0000-0002-1052-1104Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Research Focus:protein folding & dynamics· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

David RhyneriD· 2 shared Jason GreenwaldiD· 2 shared Kristina BiedermanniD· 2 shared Roland RiekiD· 2 shared Andrzej Jerzy RzepielaiD· 1 shared Dhiman GhoshiD· 1 shared Konrad KaranowskiiD· 1 shared Maciej ZiębaiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

David RhynerORCID

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3 papers

Recent·Most cited

Cryo-EM structures of Alpha-Synuclein(31-100) amyloid fibrils reveal disease-like structural motifs without reproducing the Parkinson's Disease polymorph

Kristina Biedermann, David Rhyner, Lukas Frey, Roland Riek, Jason Greenwald

The paper uses cryo-EM to determine amyloid fibril structures of a truncated alpha-synuclein construct, revealing disease-like motifs without forming the Parkinson's Disease polymorph.

bioRxiv · Jul 21, 2026 · PreprintBiophysics

On the Polymorph-Selection Determinants of α-Synuclein Amyloid Fibrils Studied at Atomic Resolution

Lukas Frey, David Rhyner, Witek Kwiatkowski, Dhiman Ghosh, Kristina Biedermann, Roland Riek, Jason Greenwald

This study investigates factors influencing the formation of α-synuclein amyloid fibrils at atomic resolution using cryo-electron microscopy.

bioRxiv · Jul 16, 2026 · PreprintBiophysics

Point-Cloud Enhancement and Structural Interpretation Framework for Cryo-EM Maps

Konrad Karanowski, Milosz Chojecki, Andrzej Jerzy Rzepiela, Mateusz Grzesiuk, Radosław Kuczbański, Lukas Frey, Maciej Zięba

This paper introduces CryoPC, a framework that enhances cryo-EM maps by incorporating global structural context, improving enhancement quality and providing a quality assessment framework.

bioRxiv · Jan 21, 2026 · PreprintBioinformatics