Hamish A Deery

A Comparison of Brain Metabolic Connectivity Methods Topology, Cognition, Age, Structure, and Genetics

This paper compares brain metabolic connectivity methods using PET and fMRI data, finding that different approaches yield distinct topological, cognitive, structural, and genetic signatures, with fPET showing strongest cognitive associations and age-related declines.

Directed information flow across the metabolic network of the human brain

The paper uses fPET and Granger causality to analyze directed metabolic connectivity in brain circuits, finding that metabolic connections predict cognition and affect, and vary in efficiency and functional benefit.

Metabolic brain networks switch between a sparsely connected baseline and highly integrated states to support cognition

This study identifies four metabolic network states in the human brain and shows that cognitive performance depends on the ability to switch between them, with reduced flexibility in older adults.

Metabolic Connectivity Gradients of the Human Brain

This study identifies four metabolic connectivity gradients in the human brain, linking metabolic activity, cortical structure, and cognitive function across the lifespan.

Brain glucodynamic variability is an essential feature of the metabolism-cognition relationship

This study shows that variability in glucose metabolism, not just average rates, is linked to cognitive performance and metabolic network efficiency, with reduced variability in older adults associated with worse cognition.

Metabolic connectivity has greater predictive utility for age and cognition than functional connectivity.

This study compares metabolic and functional connectivity using fPET and fMRI to determine their predictive power for age and cognition, finding that metabolic connectivity is more predictive.

Sex differences in the rates and association of cerebral blood flow and glucose metabolism in normative ageing.

This study examines sex differences in the relationship between cerebral blood flow and glucose metabolism across age groups and finds that older females show stronger negative correlations, potentially indicating compensatory mechanisms.

Peripheral insulin resistance attenuates cerebral glucose metabolism and impairs working memory in healthy adults

The paper investigates how peripheral insulin resistance affects cerebral glucose metabolism and working memory in healthy adults, finding greater impacts in younger adults.

Metabolic connectivity in ageing.

This study examines metabolic connectivity in ageing using high temporal resolution PET, finding reduced connectivity and altered topology in older adults linked to worse cognitive performance.

Insulin resistance alters the coupling between cerebral blood flow and glucose metabolism in younger and older adults: Implications for neurovascular coupling

This study examines how insulin resistance and age affect cerebral blood flow and glucose metabolism coupling in adults, finding altered coupling patterns in insulin-resistant individuals.

Lower Brain Glucose Metabolism in Normal Ageing is Predominantly Frontal and Temporal: A Systematic Review and Pooled Effect Size and Activation Likelihood Estimates Meta-Analyses.

This paper conducts a systematic review and meta-analyses of cerebral glucose metabolism in ageing, finding reduced metabolism in frontal and temporal regions.