Laura E. Hughes

From group-level neurophysiological biomarkers to individual-level phenotyping to identify mechanisms of neurodegenerative disease

This paper translates group-level neurophysiological biomarkers into individual-level phenotyping to identify mechanisms of neurodegenerative diseases using MEG data.

Apathy as a Loss of Prior Precision on Action Outcomes

This study investigates apathy as a reduction in prior precision of action outcome beliefs, finding a negative correlation between prior precision and apathy in healthy adults.

Neurochemistry-enriched dynamic causal models of magnetoencephalography, using magnetic resonance spectroscopy

This paper develops a Bayesian framework integrating MEG and 7T-MRS to infer synaptic connectivity influenced by neurotransmitter concentrations, confirming GABA and glutamate effects on specific cortical connections.

GABA-ergic dynamics in human frontotemporal networks confirmed by pharmaco-magnetoencephalography.

The paper uses dynamic causal models and pharmaco-magnetoencephalography to study GABAergic dynamics in human frontotemporal networks and identifies drug effects on neuronal function.

In vivo assay of cortical microcircuitry in frontotemporal dementia: a platform for experimental medicine studies

This paper uses machine learning to analyze magnetoencephalography data from bvFTD patients to identify pathophysiological changes and improve case-control classification.