GeneticsMovement DisordersPeer-reviewed
Parkinson disease age of onset GWAS: defining heritability, genetic loci and a-synuclein mechanisms
Cornelis Blauwendraat, Karl Heilbron, Costanza Ludovica Vallerga…·Andrew Singleton
This study conducts a GWAS to identify genetic determinants of Parkinson's disease age of onset, finding associations with SNCA, TMEM175, and GBA, and highlighting alpha-synuclein's role in disease onset.
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