Kajal Charan

This study develops a mathematical model of PPARγ dynamics to show stress-induced adipogenic commitment is a bistable, irreversible process regulated by circadian rhythms.

The paper constructs a network model to identify crosstalk between p53 and cell-cycle regulators, revealing mechanisms enabling cells to escape cell-cycle arrest and undergo mitotic catastrophe.

The paper models how transcriptional memory fluctuations and mitotic resetting influence cell cycle duration heterogeneities across lineage pairs.