Prostacyclin promotes degenerative pathology in a model of Alzheimer's disease
Tasha Womack, Craig T. Vollert, Odochi Ohia-Nwoko, Monika E. Schmitt, Saghi Montazari, Tina L. Beckett, David Matthew Mayerich, Michael Paul Murphy, Jason L. Eriksen
This study shows that increased prostacyclin biosynthesis in a mouse model of Alzheimer's disease worsens amyloid pathology, impairs cognition, and damages the microvasculature.
Frontiers in Cellular Neuroscience · Feb 6, 2022Peer-reviewedNeuroscience