This study identifies genetic associations with Parkinson disease motor subtypes using GWAS, finding novel variants and suggesting overlap with essential tremor genetics.

42 citations

humanGWAS summary statistics

𝕏 PostBluesky

GeneticsbioRxivPreprintNov 11, 2019

Integrated Sequencing & Array Comparative Genomic Hybridization in Familial Parkinson’s Disease

Laurie A. Robak, Renqian Du, Bo Yuan…·Joshua M Shulman

The paper combines exome sequencing and array-based comparative genomic hybridization to identify genetic risk factors in familial Parkinson’s disease, finding novel SNVs and CNVs.

1 citation

humanwhole-exome sequencing

𝕏 PostBluesky

GeneticsThe Lancet NeurologyPeer-reviewedNov 6, 2019

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Expanding Parkinson’s disease genetics: novel risk loci, genomic context, causal insights and heritable risk

Mike A. Nalls, Cornelis Blauwendraat, Costanza Ludovica Vallerga…·Ciara García

Across 37,688 Parkinson's cases, 18,618 proxy-cases and 1.4M controls, 90 risk signals map to 78 loci (37 new); an 1805-variant polygenic score explains 26-36% of heritability.

2,451 citationstop 1%

humanGWAS summary statistics

𝕏 PostBluesky

Additional preprints under this name without ORCID

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Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes

Integrated Sequencing &amp; Array Comparative Genomic Hybridization in Familial Parkinson’s Disease

Expanding Parkinson’s disease genetics: novel risk loci, genomic context, causal insights and heritable risk

Integrated Sequencing & Array Comparative Genomic Hybridization in Familial Parkinson’s Disease