Systems BiologybioRxivPreprint
A trajectory-coupled network bottleneck governs gemcitabine resistance in 3D PDAC tissue models
MARYAM ALMASI, Jesús Guillermo Nieves Pereira, Thomas Dandekar…·Johannes Balkenhol
The paper identifies a CDK1-CDKN1A-WEE1 bottleneck in gemcitabine resistance using trajectory-coupled network analysis in PDAC models and patient data.