The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation
Daniel Seung Kim, Viviana I. Risca, David L. Reynolds, James Chappell, Adam J. Rubin, Namyoung Jung, Laura K. H. Donohue, Vanessa Lopez-Pajares, Arwa S. Kathiria, Minyi Shi, Zhixin Zhao, Harsh Deep, Mahfuza Sharmin, Deepti S. Rao, Shin Lin, , Paul A. Khavari
The paper identifies dynamic cis-regulatory elements in epidermal differentiation using multi-omic data and deep learning, revealing combinatorial motif rules linked to gene expression and polygenic skin disease.
Nature Genetics · Oct 14, 2021Peer-reviewedGenomics