Vanessa Lopez-Pajares

The paper shows that dermal-epidermal junction geometry influences stem cell fate in mouse skin, with concave areas promoting proliferation and convex areas promoting differentiation.

The paper identifies ADGRL2's role in epidermal differentiation through Gα13 activation and structural interactions, using CRISPR, Perturb-seq, and cryo-EM.

The paper identifies disease-linked regulatory DNA variants and their impact on epidermal homeostasis by analyzing SNVs, TF binding, and gene dysregulation in polygenic skin diseases.

This study identifies glucose-binding proteins TSC22D4 and IGF2BP2 using thermal proteome profiling, showing their roles in metabolic disease and insulin secretion.

This study shows glucose acts as a morphogen that modulates transcription factor dimerization during tissue differentiation.

The paper identifies dynamic cis-regulatory elements in epidermal differentiation using multi-omic data and deep learning, revealing combinatorial motif rules linked to gene expression and polygenic skin disease.