Machine Learning-Driven Optimization of Specific, Compact, and Efficient Base Editors via Single-Round Diversification
Mykyta Ielanskyi, Meng Wang, Lewis Scott, Lila Rieber, Stephanie L. Merrett, Johannes Schimunek, Andreas Mayr, Ian C. McDowell, Günter Klambauer, Tyson Bowen
This paper develops novel base editors by diversifying TadA orthologs and using generative models to optimize specificity and efficiency.
Nucleic Acids Research · May 16, 2026Peer-reviewedBioengineering