Author

Tyson Bowen

ORCID 0009-0002-0229-0817Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:database / resource· 1 Approach:deep learning· 1 Assay:metagenomics· 1 Research Focus:protein design· 1 Approach:statistical model· 1

Frequent Co-Authors

Lila Rieber· 2 shared Meng WangiD· 2 shared Andreas MayriD· 1 shared Emmanuel LC de los Santos· 1 shared Günter KlambaueriD· 1 shared Ian C. McDowelliD· 1 shared Johannes SchimunekiD· 1 shared Lewis Scott· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioengineering

Lila Rieber

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BioengineeringNucleic Acids ResearchPeer-reviewedMay 16, 2026

Machine Learning-Driven Optimization of Specific, Compact, and Efficient Base Editors via Single-Round Diversification

Mykyta Ielanskyi, Meng Wang, Lewis Scott…·Tyson Bowen

This paper develops novel base editors by diversifying TadA orthologs and using generative models to optimize specificity and efficiency.

DOI 10.1093/nar/gkag545

deep learningprotein design

𝕏 PostBluesky

GenomicsbioRxivPreprintMay 15, 2026

Structure-Led Exploration of the Metagenome Yields Novel RNA-Guided Nucleases with Broad PAM Diversity

Emmanuel LC de los Santos, Lila Rieber, Meng Wang…·Tyson Bowen

The paper identifies novel RNA-guided nucleases with broad PAM diversity using structure-led metagenomic analysis, expanding genome editing capabilities.

DOI 10.64898/2026.03.27.714800

metagenomicsstatistical model

𝕏 PostBluesky