Josée Dostie

The paper performs knockdown of 200 lncRNAs in human iPS cells, identifies 36 with growth inhibition, and finds molecular phenotypes in 29.3% of cases, with higher agreement in molecular than cell growth phenotypes across cell types.

This study identifies a conserved HOTAIRM1-HOXA1 regulatory axis that coordinates early neuronal differentiation by modulating pluripotency networks and HOXA gene expression.

The paper identifies cis-interacting lncRNAs and their targets using RNA-chromatin and Hi-C data across 18 human cell types.

The paper functionally annotates human long non-coding RNAs by systematically knocking down 285 lncRNAs and analyzing molecular phenotypes using CAGE sequencing.

This paper introduces HIFI, a method to estimate DNA-DNA interaction frequencies at restriction-fragment resolution from Hi-C data, improving resolution and biological insights.