Engineered bacterial M1GS ribozyme efficiently cleaves the most abundant ribosomal RNA in a human cancer cell line
Neha Priyadarshini, Navinchandra Venkatarama Puppala, Harikrishnan Poiyamozhi, Swati Biswas, Gireesha Mohannath
The paper develops a tool to predict M1GS ribozyme target sites and demonstrates its efficiency in downregulating 28S rRNA in a human cancer cell line.
bioRxiv · Nov 7, 2025 · PreprintMolecular Biology