Nicholas Delihas

The paper analyzes the evolutionary development of regulatory elements in the human bicistronic gene SMIM45, identifying diverse mechanisms for the formation of super-enhancers and super-silencers over millions of years.

The paper investigates the evolutionary origin of a human de novo ORF, showing it developed from a non-primate non-coding region through biased random mutations during primate evolution.

The paper identifies a conserved non-coding spacer sequence that acts as a nucleation site for de novo gene formation in primates, leading to the birth of genes like BCRP3.

The paper identifies an ancestral conserved repeat sequence in human and chimpanzee genomes that gives rise to diverse non-coding RNA genes and pseudogenes in humans but not chimpanzees.