This paper addresses bias in cortical thickness estimation in UK Biobank by using harmonisation methods to correct for batch effects caused by missing T2-FLAIR data.

bioRxiv · May 26, 2026 · PreprintNeuroscience

Genome-wide analysis identifies 66 variants underlying anatomical variation in human neuroendocrine structures and reveals links to testosterone

Hannah Currant, Christoph Arthofer, Teresa Cruz Ferreira, Gwenaëlle Douaud, Barney Hill, Samvida S. Venkatesh, Nikolas A. Baya, Duncan S. Palmer, Saskia Reibe, Anje Moltke-Prehn, Tune H. Pers, A Bartsch, Jesper Andersson, Margaret Flynn Lippincott, Yee-Ming Chan, , Cecilia M. Lindgren

This study identifies 66 genetic variants linked to neuroendocrine structure volumes and links some to testosterone levels using UK Biobank data.

medRxiv · Aug 1, 2024 · PreprintGenetic & Genomic Medicine

Internally-consistent and fully-unbiased multimodal MRI brain template construction from UK Biobank: Oxford-MM

Christoph Arthofer, Stephen M. Smith, Gwenaëlle Douaud, Andreas Bartsch, Fidel Alfaro‐Almagro, Jesper Andersson, Frederik Lange

This paper constructs internally-consistent, fully-unbiased multimodal MRI brain templates from UK Biobank data, showing improved registration accuracy compared to existing templates.

Imaging Neuroscience · Jan 1, 2024Peer-reviewedNeuroscience

MMORF - FSL's MultiMOdal Registration Framework

Frederik Lange, Christoph Arthofer, Andreas Bartsch, Gwenaëlle Douaud, Paul McCarthy, Stephen M. Smith, Jesper Andersson

MMORF is a nonlinear image registration tool for MRI brain images that outperforms existing methods in accuracy and distortion control across multiple domains.

Imaging Neuroscience · Jan 1, 2024Peer-reviewedNeuroscience

Estimating axial diffusivity in the NODDI model

Amy F.D. Howard, Michiel Cottaar, Mark Drakesmith, Qiuyun Fan, Susie Y. Huang, Derek Kenton Jones, Frederik Lange, Jeroen Mollink, Suryanarayana Umesh Rudrapatna, Qiyuan Tian, Karla L. Miller, Saâd Jbabdi

This paper estimates axial diffusivity in the NODDI model using high b-value data and shows the impact of noise assumptions on parameter estimates.

NeuroImage · Aug 2, 2022Peer-reviewedNeuroscience

A Symmetric Prior for the Regularisation of Elastic Deformations: Improved Anatomical Plausibility in Nonlinear Image Registration

Frederik Lange, John Ashburner, Stephen M. Smith, Jesper Andersson

This paper introduces a symmetric prior for regularizing nonlinear image registration, improving anatomical plausibility while maintaining or exceeding registration quality.

NeuroImage · Jun 1, 2020Peer-reviewedNeuroscience