Author
Broad InstituteORCID 0000-0002-4681-374XUnclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
13 papers
Recent·Most cited
Duncan S. Palmer, Barney Hill, Sam Hodgson…·Benjamin M. Neale
The paper establishes a global consortium to discover rare genetic associations by integrating data from multiple biobanks, identifying 514 gene-trait associations, many detectable only through cross-ancestry meta-analysis.
Nikolas A. Baya, Frederik Heymann Lassen, Barney Hill…·Duncan Stuart Palmer
The paper identifies rare damaging variants in genes associated with misaligned phenotypes using polygenic scores and enrichment analysis in the UK Biobank.
Nikolas A. Baya, İlknur Sur‐Erdem, Samvida S. Venkatesh…·Cecilia M. Lindgren
The paper identifies genes associated with obesity and fat distribution using genetic and functional data, then validates their roles through CRISPR knockdown in cell lines.
Samvida S. Venkatesh, Laura B. L. Wittemans, Duncan S. Palmer…·Cecilia M. Lindgren
This study identifies 21 infertility loci and over 400 reproductive hormone loci through GWAS across multiple cohorts, finding limited genetic correlation between reproductive hormones and infertility.
Hannah Currant, Christoph Arthofer, Teresa Cruz Ferreira…·Cecilia M. Lindgren
This study identifies 66 genetic variants linked to neuroendocrine structure volumes and links some to testosterone levels using UK Biobank data.
Frederik Heymann Lassen, Samvida S. Venkatesh, Nikolas A. Baya…·Duncan S. Palmer
The paper identifies compound heterozygous variants in UK Biobank data and shows their phenotypic impact on common diseases using statistical phasing and mixed models.
Evan M Koch, Noah J Connally, Nikolas A. Baya…·Shamil R. Sunyaev
The paper analyzes GWAS data for 27 traits to test evolutionary models, finding most traits are consistent with stabilizing selection rather than neutral evolution or directional selection.
Konrad J. Karczewski, Rahul Gupta, Masahiro Kanai…·Alicia R. Martin
Meta-analyzing per-ancestry GWAS of 7,266 UK Biobank traits across six genetic ancestry groups adds 14,676 loci missed by European-only analysis, including ancestry-enriched CAMK2D and G6PD signals.
Luke Anderson-Trocmé, Dominic Nelson, Shadi Zabad…·Simon Gravel
The paper models French Canadian ancestry using genealogical and genetic data, revealing population structure shaped by geography and migration.
Duncan S. Palmer, Wei Zhou, Liam E. Abbott…·Benjamin M. Neale
The paper evaluates dominance effects in over 1,000 UK Biobank phenotypes using GWAS, finding no significant dominance contribution to phenotypic variance from common variation.
Emilie M. Wigdor, Daniel J. Weiner, Jakob Grove…·Elise Robinson
The paper investigates the female protective effect against autism spectrum disorder by analyzing genetic risk in siblings and parents of ASD cases, finding evidence of sex differences in inherited genetic risk.
Gianmarco Mignogna, Caitlin E. Carey, Robbee Wedow…·Andrea Ganna
The paper identifies genetic loci associated with survey nonresponse behaviors and shows their genetic correlation with education and health.
Nicola Pirastu, Mattia Cordioli, Priyanka Nandakumar…·Andrea Ganna
The paper identifies sex-differential participation bias in genetic studies by performing GWAS on sex in 3.3 million individuals, finding 158 loci associated with sex and highlighting traits like BMI that may influence participation.