Molecular BiologyPLoS GeneticsPeer-reviewed
Deciphering novel TCF4-driven mechanisms underlying a common triplet repeat expansion-mediated disease
Nihar Bhattacharyya, Niuzheng Chai, Nathaniel J. Hafford‐Tear…·Alice E. Davidson
This study identifies two pathogenic mechanisms, RNA toxicity and TCF4 isoform dysregulation, in Fuchs endothelial corneal dystrophy using patient-derived corneal endothelial cells and multi-omics analyses.