Author

Nathaniel J. Hafford‐Tear

University College LondonORCID 0000-0001-8564-5198Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:long-read sequencing· 1 Assay:scRNA-seq· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Alice E. DavidsoniD· 2 shared Aaron R. JeffriesiD· 1 shared Alison J. HardcastleiD· 1 shared Alysha S TayloriD· 1 shared Amanda N. SadaniD· 1 shared Anita SzabóiD· 1 shared Branduff McAllisteriD· 1 shared Christina ZarouchliotiiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Alice E. DavidsonORCID

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Author profile →

2 papers

Recent·Most cited

Deciphering novel TCF4-driven mechanisms underlying a common triplet repeat expansion-mediated disease

Nihar Bhattacharyya, Niuzheng Chai, Nathaniel J. Hafford‐Tear, Amanda N. Sadan, Anita Szabó, Christina Zarouchlioti, Jana Jedličková, Szi Kay Leung, Tianyi Liao, Ľubica Ďuďáková, Pavlína Skalická, Mohit Parekh, Ismail Moghul, Aaron R. Jeffries, Michael E. Cheetham, , Alice E. Davidson

This study identifies two pathogenic mechanisms, RNA toxicity and TCF4 isoform dysregulation, in Fuchs endothelial corneal dystrophy using patient-derived corneal endothelial cells and multi-omics analyses.

PLoS Genetics · May 7, 2024Peer-reviewedMolecular Biology

Repeat Detector: versatile sizing of expanded tandem repeats and identification of interrupted alleles from targeted DNA sequencing

Alysha S Taylor, Dinis Barros, Nastassia Gobet, Thierry Schuepbach, Branduff McAllister, Lorène Aeschbach, Emma L. Randall, Evgeniya Trofimenko, Eleanor R. Heuchan, Paula Barszcz, Marc Ciosi, Joanne Morgan, Nathaniel J. Hafford‐Tear, Alice E. Davidson, Thomas H. Massey, , Vincent Dion

Repeat Detector accurately measures expanded tandem repeats and identifies interrupted alleles in targeted DNA sequencing data from Huntington's disease patients.

NAR Genomics and Bioinformatics · Oct 6, 2022Peer-reviewedNeuroscience