Prolonged tonic pain in healthy humans enhances functional connectivity of descending pain modulation networks involving the amygdala, periaqueductal gray and parabrachial nucleus to cortical sensory-discriminative areas
Timothy J. Meeker, Anne‐Christine Schmid, Michael L. Keaser, Shariq Ali Khan, Rao P. Gullapalli, Susan G. Dorsey, Joel D. Greenspan, David Anthony Seminowicz
This study shows that tonic pain in healthy humans alters functional connectivity within the Descending Pain Modulatory Network, with specific connections predicting pain intensity and being modulated by pain.
bioRxiv · Aug 31, 2021 · PreprintNeuroscience