Jonathan Deaton

The paper uses language modeling to create a comprehensive representation of protein biology, enabling structure prediction and discovery of high-affinity protein interactions.

ESM3, a 98-billion-parameter multimodal protein language model tokenized across sequence, structure, and function, designs a bright green fluorescent protein at 58% sequence identity to known fluorescent proteins.

PhaMers identifies 103 novel phage sequences from Yellowstone hot spring metagenomes using tetranucleotide frequency analysis and compares results with VirSorter.