Systems BiologybioRxivPreprint
Binding Site-enhanced Sequence Pretraining and Out-of-cluster Meta-learning Predict Genome-Wide Chemical-Protein Interactions for Dark Proteins
Tian Cai, Li Xie, Shuo Zhang…·Lei Xie
PortalCG predicts chemical-protein interactions for dark proteins using a deep learning framework that integrates binding site information and meta-learning, outperforming existing methods in out-of-distribution scenarios.
DOI 10.1101/2022.11.15.516682