Binding Site-enhanced Sequence Pretraining and Out-of-cluster Meta-learning Predict Genome-Wide Chemical-Protein Interactions for Dark Proteins
Tian Cai, Li Xie, Shuo Zhang, Muge Chen, Di He, Amitesh Badkul, Yang Liu, Namballa Hari Krishna, Michael Dorogan, Wayne Wesley Harding, Cameron Mura, Philip E. Bourne, Lei Xie
PortalCG predicts chemical-protein interactions for dark proteins using a deep learning framework that integrates binding site information and meta-learning, outperforming existing methods in out-of-distribution scenarios.
bioRxiv · Nov 15, 2022 · PreprintSystems Biology