BiophysicsbioRxivPreprint
Atomistic Insights into TRPC6/Caveolin-1 Interactions Interface via All- Atom Molecular Dynamics Simulations: Structural and Energetic Basis for Selective Modulation
Shayesteh Bazsefidpar, Alejandro Rodriguez, Masayuki X. Mori…·Onur Kerem Polat
This study uses molecular dynamics simulations to characterize the TRPC6-CAV1 interaction, revealing an acidic patch in TRPC6 and a basic segment in CAV1 that form a cooperative binding interface with favorable binding free energy.
DOI 10.64898/2026.09.09.750526