Protein engineering via Bayesian optimization-guided evolutionary algorithm and robotic experiments
Ruyun Hu, Lihao Fu, Yongcan Chen, Junyu Chen, Yu Qiao, Tong Si
This paper introduces BO-EVO, a Bayesian optimization-guided evolutionary algorithm that improves protein engineering efficiency by enabling batched robotic experiments and achieving significant improvements in enzyme specificity.
Briefings in Bioinformatics · Nov 23, 2022Peer-reviewedSynthetic Biology