A mammalian-specific domain of MSH5 drives the transition from crossover licensing to designation during meiotic prophase I
Ky’ara D. Carr, Eliza O'Donnell, Tegan S. A. Horan, Maame Serwaa Adjei-Boadu, Anna J. Wood, Yongwei Zhang, Winfried Edelmann, María de las Mercedes Carro, Paula E. Cohen
This study shows that a mammalian-specific domain of MSH5 is essential for converting licensed DSB repair intermediates to designated class I crossovers during meiosis.
bioRxiv · Jun 18, 2026 · PreprintGenetics