Chiral methionine oxidation reagents reveal stereospecific proteome modifications
Angel Gonzalez-Valero, Annika C. S. Page, Jayde M. Bertoch, Fadi Alsarhan, Jaehee Kim, Amr A. Alazali, Ritwik R. Srinivas, Xiao Xie, Audrey G. Reeves, Kacper Skakuj, Theodore G. Coffey, Scott C. Virgil, Jordan Nafie, Dan He, Nam Dao, , Christopher J. Chang
The paper develops chiral reagents to identify stereospecific methionine oxidation sites and shows their functional impact on protein activity in oxidative stress models.
bioRxiv · Mar 26, 2026 · PreprintBiochemistry