Tjaša Kumelj

Competing constraints on protein availability and nutrient uptake reshape yeast genetic interactions

The paper shows that genetic interactions in yeast change with protein availability and nutrient uptake, revealing new insights into how metabolic constraints affect epistasis.

Genome-scale metabolic modelling when changes in environmental conditions affect biomass composition

This paper introduces two computational methods, BTW and HIP, to improve genome-scale metabolic models by accounting for environmental effects on biomass composition, showing differences in model performance and phenotypic predictions.

Enzyme-constrained models and omics analysis of Streptomyces coelicolor reveal metabolic changes that enhance heterologous production

The paper compares metabolic differences between Streptomyces coelicolor strains M1152 and M145 using omics data and a genome-scale model to identify metabolic changes affecting heterologous compound production.