Christian Schulz

A study of a diauxic growth experiment using an expanded dynamic flux balance framework

The paper develops decFBAecc, an extended dynamic flux balance analysis method that incorporates enzyme change constraints, and validates it using diauxic growth experiments in E. coli.

Quantification of macromolecular biomass composition for constraint-based metabolic modeling

The paper develops a pipeline for experimental biomass quantification in E. coli, improving coverage and resolution, and evaluates its impact on metabolic model predictions.

Genome-scale metabolic modelling when changes in environmental conditions affect biomass composition

This paper introduces two computational methods, BTW and HIP, to improve genome-scale metabolic models by accounting for environmental effects on biomass composition, showing differences in model performance and phenotypic predictions.

Genome-scale reconstructions to assess metabolic phylogeny and organism clustering

The paper constructs genome-scale metabolic reconstructions for 975 organisms using AutoKEGGRec and uses them to generate phylogenetic trees that closely resemble the Tree of Life.