Elevated Ubiquitin Phosphorylation by PINK1 Contributes to Proteasomal Impairment and Promotes Neurodegeneration
Cong Chen, Tong‐Yao Gao, Hua-Wei Yi, Yi Zhang, Tong Wang, Zhiling Lou, Tao-Feng Wei, Yun‐Bi Lu, Tingting Li, Chun Tang, Wei‐Ping Zhang
This study shows that elevated phosphorylated ubiquitin (pUb) caused by PINK1 impairs proteasomal activity and promotes neurodegeneration in multiple conditions.
eLife · Jul 31, 2025Peer-reviewedBiochemistry