Man Chun John Ma

Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma

This study identifies subtype-specific and co-occurring genetic alterations across major B-NHL subtypes using targeted sequencing of 380 genes in 685 tumors.

Targetable genetic alterations of TCF4 (E2-2) drive immunoglobulin expression in the activated B-cell subtype of diffuse large B-cell lymphoma

The paper identifies TCF4 overexpression driven by 18q21.2 gains as a mechanism promoting IgM expression in ABC-like DLBCL and shows BET inhibitors can suppress it.

Genome variation and conserved regulation identify genomic regions responsible for strain specific phenotypes in rat

The paper identifies strain-specific genomic regions associated with metabolic syndrome in rats by integrating genomic variation and regulatory conservation.