Urinary proteins from Sickle Cell patients induce inflammation and kidney injury via the TGFβ-p53 axis in a podocyte cell culture model.
Wasco Wruck, Abida Islam Pranty-Weßelmann, Chantelle Thimm, Christiane Loerch, Rosanne Mack, Theresa Koranteng, Vincent Boima, Yvonne Dei‐Adomakoh, Margaret Yaa Lartey, James Adjaye
This study identifies upregulated proteins in SCD patients with proteinuria and links them to inflammation and kidney injury via the TGFβ-p53 axis in podocyte cultures.
bioRxiv · Aug 8, 2025 · PreprintMolecular Biology