Christiane Loerch

The paper uses iPSC-derived liver cells to show SAHA reduces Z-alpha-1-antitrypsin polymers by increasing chaperone expression in AATD models.

This study shows DPP4 inhibition alters metabolism and inflammation pathways in steatotic hiPSC-derived HLCs, suggesting potential therapeutic benefits for MAFLD.

This study identifies upregulated proteins in SCD patients with proteinuria and links them to inflammation and kidney injury via the TGFβ-p53 axis in podocyte cultures.

This study examines BPDE toxicity in hiPSCs and NPCs, revealing hiPSCs are more sensitive to BPDE with enhanced p53-mediated DNA damage response, and NBS patient cells show reduced apoptosis.