Author

Joseph R. Sachleben

University of ChicagoORCID 0000-0002-2018-1326Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Esmael J. HaddadianiD· 1 shared Isabelle A. GagnoniD· 1 shared Jake WilliamsiD· 1 shared Karl F. FreediD· 1 shared Sashin Natesh· 1 shared Stephen C. MeredithiD· 1 shared Tobin R. SosnickiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 11 mutual co-author links

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1 shared paperNeuroscience

Esmael J. HaddadianORCID

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2 papers

Recent·Most cited

NMR Spectroscopy for the Validation of AlphaFold2 Structures

Jake Williams, Isabelle A. Gagnon, Joseph R. Sachleben

The paper develops heuristics and a support vector machine to validate AlphaFold2 structures using NMR spectra, testing their ability to identify inaccurate predictions.

bioRxiv · Feb 4, 2025 · PreprintBiophysics

Aβ Fibrils Can Act as Aqueous Pores: a Molecular Dynamics Study

Sashin Natesh, Joseph R. Sachleben, Tobin R. Sosnick, Karl F. Freed, Stephen C. Meredith, Esmael J. Haddadian

This study uses molecular dynamics simulations to show that Aβ fibrils can form aqueous pores, allowing water and ion flow through their structure.

bioRxiv · Sep 14, 2018 · PreprintNeuroscience