Tobin R. Sosnick

CRANBERRY: A Coarse-grained RNA Model with Sugar Puckering and Noncanonical Base Pairing

CRANBERRY is a coarse-grained RNA model that includes sugar puckering and noncanonical base pairing, achieving performance comparable to all-atom models in structural predictions and experimental agreement.

Dynamic myosin 10 coupling to DCC and β1 integrin is mediated by intrinsically disordered regions during filopodial transport and patterning

This study shows how Myo10 uses intrinsically disordered regions to bind different cargos, DCC and β1 integrin, through distinct mechanisms involving disorder-to-order transitions and fuzzy binding.

Transcriptome-wide mRNP condensation precedes stress granuleformation and excludes new mRNAs

The paper shows that mRNAs condense broadly in yeast under stress, independent of length, and new transcripts escape this condensation for selective translation.

Structural Mechanism of Prestin-Membrane Mechanotransduction

This study reveals how prestin translates membrane tension into charge and motor movement during sound-evoked vibrations through structural analysis and complementary experiments.

Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity

This study characterizes IDE conformational dynamics using cryo-EM and MD simulations, identifying key residues and mechanisms that modulate enzyme activity.

Aβ Fibrils Can Act as Aqueous Pores: a Molecular Dynamics Study

This study uses molecular dynamics simulations to show that Aβ fibrils can form aqueous pores, allowing water and ion flow through their structure.

Trajectory-Based Parameterization of a Coarse-Grained Forcefield for High-Throughput Protein Simulation

The paper trains a coarse-grained forcefield using contrastive divergence on simulation trajectories to improve protein folding accuracy while maintaining computational efficiency.