Author

Keisha N. Hardeman

Vanderbilt UniversityORCID 0000-0002-2032-7399Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

B. Bishal PaudeliD· 2 shared Corey E. HayfordiD· 2 shared Vito QuarantaiD· 2 shared Charles T. RobbinsiD· 1 shared Dongya JiaiD· 1 shared Herbert LevineiD· 1 shared JOHN A. JUN. MCLEANiD· 1 shared José N. OnuchiciD· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersSystems Biology

B. Bishal PaudelORCID

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2 papers

Recent·Most cited

Drug-tolerant idling melanoma cells exhibit theory-predicted metabolic low-low phenotype

Dongya Jia, B. Bishal Paudel, Corey E. Hayford, Keisha N. Hardeman, Herbert Levine, José N. Onuchic, Vito Quaranta

The paper identifies a drug-tolerant metabolic state in melanoma cells that reduces both glycolysis and oxidative phosphorylation, supporting survival but limiting growth.

Frontiers in Oncology · Aug 14, 2020Peer-reviewedSystems Biology

Disruption of Redox Balance Enhances the Effects of BRAF-inhibition in Melanoma Cells

B. Bishal Paudel, Joshua E. Lewis, Keisha N. Hardeman, Corey E. Hayford, Charles T. Robbins, Simona G. Codreanu, Stacy D. Sherrod, JOHN A. JUN. MCLEAN, Melissa Lambeth Kemp, Vito Quaranta

The paper shows that increased antioxidant capacity in BRAF-mutated melanoma cells reduces sensitivity to BRAF inhibitors and suggests targeting redox pathways could improve treatment outcomes.

bioRxiv · Oct 28, 2019 · PreprintSystems Biology