Exposing the Molecular Reaction Blind Spots of LLMs with PathwayQA
Gowri Nayar, Kristy A. Carpenter, Delaney A. Smith, Betty Xiong, Russ Biagio Altman
This study evaluates LLMs' ability to infer biochemical reactions and disease associations from protein pathways, finding poor performance and introducing a benchmark dataset.
bioRxiv · Aug 12, 2025 · PreprintBioinformatics