BioinformaticsbioRxivPreprint
Exposing the Molecular Reaction Blind Spots of LLMs with PathwayQA
Gowri Nayar, Kristy A. Carpenter, Delaney A. Smith…·Russ Biagio Altman
This study evaluates LLMs' ability to infer biochemical reactions and disease associations from protein pathways, finding poor performance and introducing a benchmark dataset.
DOI 10.1101/2025.08.12.669911