Cancer BiologyRedox BiologyPeer-reviewed
Unravelling the anti-cancer mechanisms elicited by non-covalent thioredoxin reductase inhibitors for triple negative breast cancer therapy.
Abigail Rullo, Brenna Flowers, Keacha Chang…·Irida Kastrati
This study identifies non-covalent TXNRD inhibitors that block TNBC cell proliferation by depleting deoxynucleotides and inhibiting ribonucleotide reductase, challenging the pro-oxidant mechanism paradigm.
3 citations