Mediator 1 ablation induces enamel-to-hair lineage conversion through enhancer dynamics
Roman Thaler, Keigo Yoshizaki, Thai Nguyen, Satoshi Fukumoto, Pamela K. Den Besten, Daniel D. Bikle, Yuko Oda
This study shows that Med1 deletion in dental epithelia causes a shift from enamel to hair lineage through changes in enhancer dynamics and transcriptional programs.
bioRxiv · Sep 8, 2022 · PreprintDevelopmental Biology